Def-6, a Novel Regulator of Small GTPases in Podocytes, Acts Downstream of Atypical Protein Kinase C (aPKC) λ/ι

The atypical protein kinase C (aPKC) isotypes PKCλ/ι and PKCζ are both expressed in podocytes; however, little is known about differences in their function. Previous studies in mice have demonstrated that podocyte-specific loss of PKCλ/ι leads to a severe glomerular phenotype, whereas mice deficient...

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Veröffentlicht in:Am J Pathol
Hauptverfasser: Worthmann, Kirstin, Leitges, Michael, Teng, Beina, Sestu, Marcello, Tossidou, Irini, Samson, Thomas, Haller, Hermann, Huber, Tobias B., Schiffer, Mario
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707189/
https://ncbi.nlm.nih.gov/pubmed/24096077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.08.026
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