A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

Biallelic inactivation of BRCA1/2 is associated with a pattern of genome-wide mutations known as Signature 3. By analyzing ~1,000 breast cancer samples, we confirmed this association and established that germline nonsense and frameshift variants in PALB2, but not ATM or CHEK2, can also give rise to...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Genet
Main Authors: Polak, Paz, Kim, Jaegil, Braunstein, Lior Z., Tiao, Grace, Karlic, Rosa, Rosebrock, Daniel, Livitz, Dimitri, Kübler, Kirsten, Mouw, Kent W., Haradhvala, Nicholas J., Kamburov, Atanas, Maruvka, Yosef E., Leshchiner, Ignaty, Lander, Eric S., Golub, Todd, Zick, Aviad, Orthwein, Alexandre, Lawrence, Michael S., Batra, Rajbir N., Caldas, Carlos, Haber, Daniel A., Laird, Peter W., Shen, Hui, Ellisen, Leif W., D’Andrea, Alan, Chanock, Stephen J., Foulkes, William D., Getz, Gad
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376751/
https://ncbi.nlm.nih.gov/pubmed/28825726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3934
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker