Mutational strand asymmetries in cancer genomes reveal mechanisms of DNA damage and repair

Mutational processes constantly shape the somatic genome, leading to immunity, aging, and other diseases. When cancer is the outcome, we are afforded a glimpse into these processes by the clonal expansion of the malignant cell. Here, we characterize a less explored layer of the mutational landscape...

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Библиографические подробности
Опубликовано в: :Cell
Главные авторы: Haradhvala, Nicholas J., Polak, Paz, Stojanov, Petar, Covington, Kyle R., Shinbrot, Eve, Hess, Julian, Rheinbay, Esther, Kim, Jaegil, Maruvka, Yosef, Braunstein, Lior Z., Kamburov, Atanas, Hanawalt, Philip C., Wheeler, David A., Koren, Amnon, Lawrence, Michael S., Getz, Gad
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753048/
https://ncbi.nlm.nih.gov/pubmed/26806129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.12.050
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