Mutational strand asymmetries in cancer genomes reveal mechanisms of DNA damage and repair

Mutational processes constantly shape the somatic genome, leading to immunity, aging, and other diseases. When cancer is the outcome, we are afforded a glimpse into these processes by the clonal expansion of the malignant cell. Here, we characterize a less explored layer of the mutational landscape...

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Détails bibliographiques
Publié dans:Cell
Auteurs principaux: Haradhvala, Nicholas J., Polak, Paz, Stojanov, Petar, Covington, Kyle R., Shinbrot, Eve, Hess, Julian, Rheinbay, Esther, Kim, Jaegil, Maruvka, Yosef, Braunstein, Lior Z., Kamburov, Atanas, Hanawalt, Philip C., Wheeler, David A., Koren, Amnon, Lawrence, Michael S., Getz, Gad
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753048/
https://ncbi.nlm.nih.gov/pubmed/26806129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.12.050
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