Mutational strand asymmetries in cancer genomes reveal mechanisms of DNA damage and repair

Mutational processes constantly shape the somatic genome, leading to immunity, aging, and other diseases. When cancer is the outcome, we are afforded a glimpse into these processes by the clonal expansion of the malignant cell. Here, we characterize a less explored layer of the mutational landscape...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Haradhvala, Nicholas J., Polak, Paz, Stojanov, Petar, Covington, Kyle R., Shinbrot, Eve, Hess, Julian, Rheinbay, Esther, Kim, Jaegil, Maruvka, Yosef, Braunstein, Lior Z., Kamburov, Atanas, Hanawalt, Philip C., Wheeler, David A., Koren, Amnon, Lawrence, Michael S., Getz, Gad
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753048/
https://ncbi.nlm.nih.gov/pubmed/26806129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.12.050
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