Quantification of somatic mutation flow across individual cell division events by lineage sequencing

Mutation data reveal the dynamic equilibrium between DNA damage and repair processes in cells and are indispensable to the understanding of age-related diseases, tumor evolution, and the acquisition of drug resistance. However, available genome-wide methods have a limited ability to resolve rare som...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Brody, Yehuda, Kimmerling, Robert J., Maruvka, Yosef E., Benjamin, David, Elacqua, Joshua J., Haradhvala, Nicholas J., Kim, Jaegil, Mouw, Kent W., Frangaj, Kristjana, Koren, Amnon, Getz, Gad, Manalis, Scott R., Blainey, Paul C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280753/
https://ncbi.nlm.nih.gov/pubmed/30459213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.238543.118
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