A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages

We introduce a microfluidic platform that enables off-chip single-cell RNA-seq after multi-generational lineage tracking under controlled culture conditions. We use this platform to generate whole-transcriptome profiles of primary, activated murine CD8+ T-cell and lymphocytic leukemia cell line line...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Kimmerling, Robert J., Lee Szeto, Gregory, Li, Jennifer W., Genshaft, Alex S., Kazer, Samuel W., Payer, Kristofor R., de Riba Borrajo, Jacob, Blainey, Paul C., Irvine, Darrell J., Shalek, Alex K., Manalis, Scott R.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729820/
https://ncbi.nlm.nih.gov/pubmed/26732280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10220
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