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Passenger Hotspot Mutations in Cancer
Current statistical models for assessing hotspot significance do not properly account for variation in site-specific mutability, thereby yielding many false-positives. We thus (i) detail a Log-normal-Poisson (LNP) background model that accounts for this variability in a manner consistent with models...
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| Publicado no: | Cancer Cell |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7371346/ https://ncbi.nlm.nih.gov/pubmed/31526759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.08.002 |
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