Passenger Hotspot Mutations in Cancer

Current statistical models for assessing hotspot significance do not properly account for variation in site-specific mutability, thereby yielding many false-positives. We thus (i) detail a Log-normal-Poisson (LNP) background model that accounts for this variability in a manner consistent with models...

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Detaylı Bibliyografya
Yayımlandı:Cancer Cell
Asıl Yazarlar: Hess, Julian M., Bernards, Andre, Kim, Jaegil, Miller, Mendy, Taylor-Weiner, Amaro, Haradhvala, Nicholas J., Lawrence, Michael S., Getz, Gad
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371346/
https://ncbi.nlm.nih.gov/pubmed/31526759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.08.002
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