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A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer
Biallelic inactivation of BRCA1/2 is associated with a pattern of genome-wide mutations known as Signature 3. By analyzing ~1,000 breast cancer samples, we confirmed this association and established that germline nonsense and frameshift variants in PALB2, but not ATM or CHEK2, can also give rise to...
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| Veröffentlicht in: | Nat Genet |
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7376751/ https://ncbi.nlm.nih.gov/pubmed/28825726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3934 |
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