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Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters

Polycomb repressive complex 2 (PRC2) places H3K27me3 at developmental genes and is causally implicated in keeping bivalent genes silent. It is unclear if that silence requires minimum H3K27me3 levels and how the mark transmits faithfully across mammalian somatic cell generations. Mouse intestinal ce...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Jadhav, Unmesh, Manieri, Elisa, Nalapareddy, Kodandaramireddy, Madha, Shariq, Chakrabarti, Shaon, Wucherpfennig, Kai, Barefoot, Megan, Shivdasani, Ramesh A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376365/
https://ncbi.nlm.nih.gov/pubmed/32027840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.01.017
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