Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters

Polycomb repressive complex 2 (PRC2) places H3K27me3 at developmental genes and is causally implicated in keeping bivalent genes silent. It is unclear if that silence requires minimum H3K27me3 levels and how the mark transmits faithfully across mammalian somatic cell generations. Mouse intestinal ce...

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Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Jadhav, Unmesh, Manieri, Elisa, Nalapareddy, Kodandaramireddy, Madha, Shariq, Chakrabarti, Shaon, Wucherpfennig, Kai, Barefoot, Megan, Shivdasani, Ramesh A.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376365/
https://ncbi.nlm.nih.gov/pubmed/32027840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.01.017
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