Transcription factor-dependent ‘anti-repressive’ mammalian enhancers exclude H3K27me3 from extended genomic domains

Compacted chromatin and nucleosomes are known barriers to gene expression; the nature and relative importance of other transcriptional constraints remain unclear, especially at distant enhancers. Polycomb repressor complex 2 (PRC2) places the histone mark H3K27me3 predominantly at promoters, where i...

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Bibliographische Detailangaben
Veröffentlicht in:Genes Dev
Hauptverfasser: Saxena, Madhurima, Roman, Adrianna K. San, O'Neill, Nicholas K., Sulahian, Rita, Jadhav, Unmesh, Shivdasani, Ramesh A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5795785/
https://ncbi.nlm.nih.gov/pubmed/29321178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.308536.117
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