Dynamic reorganization of chromatin accessibility signatures during dedifferentiation of secretory precursors into Lgr5+ intestinal stem cells

Replicating Lgr5(+) stem cells and quiescent Bmi1(+) cells behave as intestinal stem cells (ISCs) in vivo. Disrupting Lgr5(+) ISCs triggers epithelial renewal from Bmi1(+) cells, from secretory or absorptive progenitors, and from Paneth cell precursors, revealing a high degree of plasticity within i...

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Gepubliceerd in:Cell Stem Cell
Hoofdauteurs: Jadhav, Unmesh, Saxena, Madhurima, O’Neill, Nicholas K., Saadatpour, Assieh, Yuan, Guo-Cheng, Herbert, Zachary, Murata, Kazutaka, Shivdasani, Ramesh A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505276/
https://ncbi.nlm.nih.gov/pubmed/28648363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.05.001
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