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Ascl2-dependent cell dedifferentiation drives regeneration of ablated intestinal stem cells
Ablation of LGR5(+) intestinal stem cells (ISCs) is associated with rapid restoration of the ISC compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but the transcriptional and signaling trajectories that guide this process are unclear, and a large body of work s...
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| Publicado no: | Cell Stem Cell |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7147146/ https://ncbi.nlm.nih.gov/pubmed/32084390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.12.011 |
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