Ascl2-dependent cell dedifferentiation drives regeneration of ablated intestinal stem cells

Ablation of LGR5(+) intestinal stem cells (ISCs) is associated with rapid restoration of the ISC compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but the transcriptional and signaling trajectories that guide this process are unclear, and a large body of work s...

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Bibliografiske detaljer
Udgivet i:Cell Stem Cell
Main Authors: Murata, Kazutaka, Jadhav, Unmesh, Madha, Shariq, van Es, Johan, Dean, Justin, Cavazza, Alessia, Wucherpfennig, Kai, Michor, Franziska, Clevers, Hans, Shivdasani, Ramesh A.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7147146/
https://ncbi.nlm.nih.gov/pubmed/32084390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.12.011
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