Extensive recovery of embryonic enhancer and gene memory stored in hypomethylated enhancer DNA

Developing and adult tissues use different cis-regulatory elements. Although DNA at some decommissioned embryonic enhancers is hypomethylated in adult cells, it is unknown whether this putative epigenetic memory is complete and recoverable. We find that in adult mouse cells, hypomethylated CpG dinuc...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Jadhav, Unmesh, Cavazza, Alessia, Banerjee, Kushal K., Xie, Huafeng, O’Neill, Nicholas K., Saenz-Vash, Veronica, Herbert, Zachary, Madha, Shariq, Orkin, Stuart H., Zhai, Huili, Shivdasani, Ramesh A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499659/
https://ncbi.nlm.nih.gov/pubmed/30905509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.02.024
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