Extensive recovery of embryonic enhancer and gene memory stored in hypomethylated enhancer DNA

Developing and adult tissues use different cis-regulatory elements. Although DNA at some decommissioned embryonic enhancers is hypomethylated in adult cells, it is unknown whether this putative epigenetic memory is complete and recoverable. We find that in adult mouse cells, hypomethylated CpG dinuc...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Jadhav, Unmesh, Cavazza, Alessia, Banerjee, Kushal K., Xie, Huafeng, O’Neill, Nicholas K., Saenz-Vash, Veronica, Herbert, Zachary, Madha, Shariq, Orkin, Stuart H., Zhai, Huili, Shivdasani, Ramesh A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499659/
https://ncbi.nlm.nih.gov/pubmed/30905509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.02.024
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