Extensive recovery of embryonic enhancer and gene memory stored in hypomethylated enhancer DNA

Developing and adult tissues use different cis-regulatory elements. Although DNA at some decommissioned embryonic enhancers is hypomethylated in adult cells, it is unknown whether this putative epigenetic memory is complete and recoverable. We find that in adult mouse cells, hypomethylated CpG dinuc...

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Publicat a:Mol Cell
Autors principals: Jadhav, Unmesh, Cavazza, Alessia, Banerjee, Kushal K., Xie, Huafeng, O’Neill, Nicholas K., Saenz-Vash, Veronica, Herbert, Zachary, Madha, Shariq, Orkin, Stuart H., Zhai, Huili, Shivdasani, Ramesh A.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499659/
https://ncbi.nlm.nih.gov/pubmed/30905509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.02.024
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