Ascl2-dependent cell dedifferentiation drives regeneration of ablated intestinal stem cells

Ablation of LGR5(+) intestinal stem cells (ISCs) is associated with rapid restoration of the ISC compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but the transcriptional and signaling trajectories that guide this process are unclear, and a large body of work s...

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Veröffentlicht in:Cell Stem Cell
Hauptverfasser: Murata, Kazutaka, Jadhav, Unmesh, Madha, Shariq, van Es, Johan, Dean, Justin, Cavazza, Alessia, Wucherpfennig, Kai, Michor, Franziska, Clevers, Hans, Shivdasani, Ramesh A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7147146/
https://ncbi.nlm.nih.gov/pubmed/32084390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.12.011
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