Acquired tissue-specific promoter bivalency is a basis for PRC2 necessity in adult cells

Bivalent promoters in embryonic stem cells (ESCs) carry methylation marks on two lysine residues, K4 and K27, in histone3 (H3). K4me2/3 is generally considered to promote transcription and Polycomb Repressive Complex 2 (PRC2) places K27me3, which is erased at lineage-restricted genes when ESCs diffe...

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Publicado en:Cell
Autores principales: Jadhav, Unmesh, Nalapareddy, Kodandaramireddy, Saxena, Madhurima, O’Neill, Nicholas K., Pinello, Luca, Yuan, Guo-Cheng, Orkin, Stuart H., Shivdasani, Ramesh A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893000/
https://ncbi.nlm.nih.gov/pubmed/27212235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.04.031
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