Single-cell transcript profiles reveal multilineage priming in early progenitors derived from Lgr5(+) intestinal stem cells

Lgr5(+) intestinal stem cells (ISC) drive epithelial self-renewal, and their immediate progeny – intestinal bipotential progenitors – produce absorptive and secretory lineages via lateral inhibition. To define features of early transit from the ISC compartment, we used a microfluidics approach to me...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Kim, Tae-Hee, Saadatpour, Assieh, Guo, Guoji, Saxena, Madhurima, Cavazza, Alessia, Desai, Niyati, Jadhav, Unmesh, Jiang, Lan, Rivera, Miguel N., Orkin, Stuart H., Yuan, Guo-Cheng, Shivdasani, Ramesh A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001892/
https://ncbi.nlm.nih.gov/pubmed/27524622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.056
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