FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

Tau aggregation into amyloid fibers based on the cross-beta structure is a hallmark of several Tauopathies, including Alzheimer Disease (AD). Trans-cellular propagation of Tau with pathological conformation has been suggested as a key disease mechanism. This is thought to cause the spreading of Tau...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Neurodegener
Egile Nagusiak: Kaniyappan, Senthilvelrajan, Tepper, Katharina, Biernat, Jacek, Chandupatla, Ram Reddy, Hübschmann, Sabrina, Irsen, Stephan, Bicher, Sandra, Klatt, Christoph, Mandelkow, Eva-Maria, Mandelkow, Eckhard
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7364478/
https://ncbi.nlm.nih.gov/pubmed/32677995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00389-1
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