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Novel antibody against low‐n oligomers of tau protein promotes clearance of tau in cells via lysosomes

INTRODUCTION: Tau, a natively unfolded soluble protein, forms abnormal oligomers and insoluble filaments in several neurodegenerative diseases, including Alzheimer disease (AD). Tau‐induced toxicity is mainly due to oligomers rather than monomers or fibrils. METHODS: We have developed monoclonal ant...

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Detalhes bibliográficos
Publicado no:Alzheimers Dement (N Y)
Main Authors: Chandupatla, Ram Reddy, Flatley, Andrew, Feederle, Regina, Mandelkow, Eva‐Maria, Kaniyappan, Senthilvelrajan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593557/
https://ncbi.nlm.nih.gov/pubmed/33145390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/trc2.12097
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