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Novel antibody against low‐n oligomers of tau protein promotes clearance of tau in cells via lysosomes
INTRODUCTION: Tau, a natively unfolded soluble protein, forms abnormal oligomers and insoluble filaments in several neurodegenerative diseases, including Alzheimer disease (AD). Tau‐induced toxicity is mainly due to oligomers rather than monomers or fibrils. METHODS: We have developed monoclonal ant...
Shranjeno v:
| izdano v: | Alzheimers Dement (N Y) |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley and Sons Inc.
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7593557/ https://ncbi.nlm.nih.gov/pubmed/33145390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/trc2.12097 |
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