Novel antibody against low‐n oligomers of tau protein promotes clearance of tau in cells via lysosomes

INTRODUCTION: Tau, a natively unfolded soluble protein, forms abnormal oligomers and insoluble filaments in several neurodegenerative diseases, including Alzheimer disease (AD). Tau‐induced toxicity is mainly due to oligomers rather than monomers or fibrils. METHODS: We have developed monoclonal ant...

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Bibliographic Details
Published in:Alzheimers Dement (N Y)
Main Authors: Chandupatla, Ram Reddy, Flatley, Andrew, Feederle, Regina, Mandelkow, Eva‐Maria, Kaniyappan, Senthilvelrajan
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593557/
https://ncbi.nlm.nih.gov/pubmed/33145390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/trc2.12097
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