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Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
Aggregation and cleavage are two hallmarks of Tau pathology in Alzheimer disease (AD), and abnormal fragmentation of Tau is thought to contribute to the nucleation of Tau paired helical filaments. Clearance of the abnormally modified protein could occur by the ubiquitin–proteasome and autophagy–lyso...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2758146/ https://ncbi.nlm.nih.gov/pubmed/19654187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp367 |
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