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Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors
Mislocalization and aggregation of the axonal protein Tau are hallmarks of Alzheimer disease and other tauopathies. Here, we studied the relationship between Tau aggregation, loss of spines and neurons, and reversibility by aggregation inhibitors. To this end we established an in vitro model of tauo...
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| Udgivet i: | Neurobiol Aging |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4984976/ https://ncbi.nlm.nih.gov/pubmed/23158765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2012.10.024 |
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