Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation

INTRODUCTION: We used an inducible mouse model expressing the Tau repeat domain with the pro-aggregant mutation ΔK280 to analyze presynaptic Tau pathology in the hippocampus. RESULTS: Expression of pro-aggregant Tau(RDΔ) leads to phosphorylation, aggregation and missorting of Tau in area CA3. To tes...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Decker, Jochen Martin, Krüger, Lars, Sydow, Astrid, Zhao, Shanting, Frotscher, Michael, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384391/
https://ncbi.nlm.nih.gov/pubmed/25853683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0193-3
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