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Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation
INTRODUCTION: We used an inducible mouse model expressing the Tau repeat domain with the pro-aggregant mutation ΔK280 to analyze presynaptic Tau pathology in the hippocampus. RESULTS: Expression of pro-aggregant Tau(RDΔ) leads to phosphorylation, aggregation and missorting of Tau in area CA3. To tes...
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| Vydáno v: | Acta Neuropathol Commun |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BioMed Central
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4384391/ https://ncbi.nlm.nih.gov/pubmed/25853683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0193-3 |
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