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Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau
Neurofibrillary lesions of abnormal Tau are hallmarks of Alzheimer´s disease and frontotemporal dementias. Our regulatable (Tet-OFF) mouse models of tauopathy express variants of human full-length Tau in the forebrain (CaMKIIα promoter) either with mutation ΔK280 (pro-aggregant) or ΔK280/I277P/I308P...
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| Publicado no: | Acta Neuropathol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4979687/ https://ncbi.nlm.nih.gov/pubmed/22532069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-012-0987-3 |
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