Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

This report describes the behavioral and electrophysiological analysis of regulatable transgenic mice expressing mutant repeat domains of human Tau (Tau(RD)). Mice were generated to express Tau(RD) in two forms, differing in their propensity for β-structure and thus in their tendency for aggregation...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Sydow, Astrid, Van der Jeugd, Ann, Zheng, Fang, Ahmed, Tariq, Balschun, Detlef, Petrova, Olga, Drexler, Dagmar, Zhou, Lepu, Rune, Gabriele, Mandelkow, Eckhard, D'Hooge, Rudi, Alzheimer, Christian, Mandelkow, Eva-Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6623704/
https://ncbi.nlm.nih.gov/pubmed/21325519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5245-10.2011
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