Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

This report describes the behavioral and electrophysiological analysis of regulatable transgenic mice expressing mutant repeat domains of human Tau (Tau(RD)). Mice were generated to express Tau(RD) in two forms, differing in their propensity for β-structure and thus in their tendency for aggregation...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Sydow, Astrid, Van der Jeugd, Ann, Zheng, Fang, Ahmed, Tariq, Balschun, Detlef, Petrova, Olga, Drexler, Dagmar, Zhou, Lepu, Rune, Gabriele, Mandelkow, Eckhard, D'Hooge, Rudi, Alzheimer, Christian, Mandelkow, Eva-Maria
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2011
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6623704/
https://ncbi.nlm.nih.gov/pubmed/21325519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5245-10.2011
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