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The Potential for β-Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

We describe two new transgenic mouse lines for studying pathological changes of Tau protein related to Alzheimer's disease. They are based on the regulatable expression of the four-repeat domain of human Tau carrying the FTDP17 (frontotemporal dementia and parkinsonism linked to chromosome 17)...

詳細記述

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書誌詳細
出版年:J Neurosci
主要な著者: Mocanu, Maria-Magdalena, Nissen, Astrid, Eckermann, Katrin, Khlistunova, Inna, Biernat, Jacek, Drexler, Dagmar, Petrova, Olga, Schönig, Kai, Bujard, Hermann, Mandelkow, Eckhard, Zhou, Lepu, Rune, Gabriele, Mandelkow, Eva-Maria
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670355/
https://ncbi.nlm.nih.gov/pubmed/18199773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2824-07.2008
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