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The Potential for β-Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

We describe two new transgenic mouse lines for studying pathological changes of Tau protein related to Alzheimer's disease. They are based on the regulatable expression of the four-repeat domain of human Tau carrying the FTDP17 (frontotemporal dementia and parkinsonism linked to chromosome 17)...

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Dettagli Bibliografici
Pubblicato in:J Neurosci
Autori principali: Mocanu, Maria-Magdalena, Nissen, Astrid, Eckermann, Katrin, Khlistunova, Inna, Biernat, Jacek, Drexler, Dagmar, Petrova, Olga, Schönig, Kai, Bujard, Hermann, Mandelkow, Eckhard, Zhou, Lepu, Rune, Gabriele, Mandelkow, Eva-Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670355/
https://ncbi.nlm.nih.gov/pubmed/18199773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2824-07.2008
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