The Potential for β-Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

We describe two new transgenic mouse lines for studying pathological changes of Tau protein related to Alzheimer's disease. They are based on the regulatable expression of the four-repeat domain of human Tau carrying the FTDP17 (frontotemporal dementia and parkinsonism linked to chromosome 17)...

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Publicado en:J Neurosci
Main Authors: Mocanu, Maria-Magdalena, Nissen, Astrid, Eckermann, Katrin, Khlistunova, Inna, Biernat, Jacek, Drexler, Dagmar, Petrova, Olga, Schönig, Kai, Bujard, Hermann, Mandelkow, Eckhard, Zhou, Lepu, Rune, Gabriele, Mandelkow, Eva-Maria
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2008
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670355/
https://ncbi.nlm.nih.gov/pubmed/18199773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2824-07.2008
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