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Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration
Missorting of Tau from axons to the somatodendritic compartment of neurons is a hallmark of Alzheimer's disease, but the mechanisms underlying normal sorting and pathological failure are poorly understood. Here, we used several Tau constructs labelled with photoconvertible Dendra2 to analyse it...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3243615/ https://ncbi.nlm.nih.gov/pubmed/22009197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.376 |
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