Aβ Oligomers Cause Localized Ca(2+) Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

Aggregation of amyloid-β (Aβ) and Tau protein are hallmarks of Alzheimer's disease (AD), and according to the Aβ-cascade hypothesis, Aβ is considered toxic for neurons and Tau a downstream target of Aβ. We have investigated differentiated primary hippocampal neurons for early localized changes...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Zempel, Hans, Thies, Edda, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633549/
https://ncbi.nlm.nih.gov/pubmed/20826658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2357-10.2010
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