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Swimming against the Tide: Mobility of the Microtubule-Associated Protein Tau in Neurons

Long-haul transport along microtubules is crucial for neuronal polarity, and transport defects cause neurodegeneration. Tau protein stabilizes microtubule tracks, but in Alzheimer's disease it aggregates and becomes missorted into the somatodendritic compartment. Tau can inhibit axonal transpor...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Konzack, Sven, Thies, Edda, Marx, Alexander, Mandelkow, Eva-Maria, Mandelkow, Eckhard
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2007
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672630/
https://ncbi.nlm.nih.gov/pubmed/17855606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0927-07.2007
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