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Swimming against the Tide: Mobility of the Microtubule-Associated Protein Tau in Neurons

Long-haul transport along microtubules is crucial for neuronal polarity, and transport defects cause neurodegeneration. Tau protein stabilizes microtubule tracks, but in Alzheimer's disease it aggregates and becomes missorted into the somatodendritic compartment. Tau can inhibit axonal transpor...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Konzack, Sven, Thies, Edda, Marx, Alexander, Mandelkow, Eva-Maria, Mandelkow, Eckhard
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672630/
https://ncbi.nlm.nih.gov/pubmed/17855606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0927-07.2007
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