Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein

Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. We are searching for low molecular weight compounds to interfere with the activity of MARK a...

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Hlavní autoři: Timm, Thomas, Marx, Alexander, Panneerselvam, Saravanan, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604893/
https://ncbi.nlm.nih.gov/pubmed/19090997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-9-S2-S9
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