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Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture
Subcellular mislocalization of the microtubule-associated protein Tau is a hallmark of Alzheimer disease (AD) and other tauopathies. Six Tau isoforms, differentiated by the presence or absence of a second repeat or of N-terminal inserts, exist in the human CNS, but their physiological and pathologic...
Zapisane w:
| Wydane w: | J Biol Chem |
|---|---|
| Główni autorzy: | , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2017
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5519369/ https://ncbi.nlm.nih.gov/pubmed/28536263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.784702 |
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