Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture

Subcellular mislocalization of the microtubule-associated protein Tau is a hallmark of Alzheimer disease (AD) and other tauopathies. Six Tau isoforms, differentiated by the presence or absence of a second repeat or of N-terminal inserts, exist in the human CNS, but their physiological and pathologic...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zempel, Hans, Dennissen, Frank J. A., Kumar, Yatender, Luedtke, Julia, Biernat, Jacek, Mandelkow, Eva-Maria, Mandelkow, Eckhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519369/
https://ncbi.nlm.nih.gov/pubmed/28536263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.784702
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados