Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

A potential strategy to alleviate the aggregation of intrinsically disordered proteins (IDPs) is to maintain the native functional state of the protein by small molecule binding. However, the targeting of the native state of IDPs by small molecules has been challenging due to their heterogeneous con...

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Publié dans:Curr Alzheimer Res
Auteurs principaux: Pickhardt, Marcus, Neumann, Thomas, Schwizer, Daniel, Callaway, Kari, Vendruscolo, Michele, Schenk, Dale, St. George-Hyslop, Peter, Mandelkow, Eva M., Dobson, Christopher M., McConlogue, Lisa, Mandelkow, Eckhard, Tóth, Gergely
Format: Artigo
Langue:Inglês
Publié: Bentham Science Publishers 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976804/
https://ncbi.nlm.nih.gov/pubmed/26510979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/156720501209151019104951
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