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Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology

Understanding the formation and propagation of aggregates of the Alzheimer disease-associated Tau protein in vivo is vital for the development of therapeutics for this devastating disorder. Using our recently developed live-cell aggregation sensor in neuron-like cells, we demonstrate that different...

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Detalhes bibliográficos
Main Authors: Michel, Claire H., Kumar, Satish, Pinotsi, Dorothea, Tunnacliffe, Alan, St. George-Hyslop, Peter, Mandelkow, Eckhard, Mandelkow, Eva-Maria, Kaminski, Clemens F., Kaminski Schierle, Gabriele S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887218/
https://ncbi.nlm.nih.gov/pubmed/24235150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.515445
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