Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

A potential strategy to alleviate the aggregation of intrinsically disordered proteins (IDPs) is to maintain the native functional state of the protein by small molecule binding. However, the targeting of the native state of IDPs by small molecules has been challenging due to their heterogeneous con...

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Detalhes bibliográficos
Publicado no:Curr Alzheimer Res
Main Authors: Pickhardt, Marcus, Neumann, Thomas, Schwizer, Daniel, Callaway, Kari, Vendruscolo, Michele, Schenk, Dale, St. George-Hyslop, Peter, Mandelkow, Eva M., Dobson, Christopher M., McConlogue, Lisa, Mandelkow, Eckhard, Tóth, Gergely
Formato: Artigo
Idioma:Inglês
Publicado em: Bentham Science Publishers 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976804/
https://ncbi.nlm.nih.gov/pubmed/26510979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/156720501209151019104951
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