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Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

A potential strategy to alleviate the aggregation of intrinsically disordered proteins (IDPs) is to maintain the native functional state of the protein by small molecule binding. However, the targeting of the native state of IDPs by small molecules has been challenging due to their heterogeneous con...

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Dettagli Bibliografici
Pubblicato in:Curr Alzheimer Res
Autori principali: Pickhardt, Marcus, Neumann, Thomas, Schwizer, Daniel, Callaway, Kari, Vendruscolo, Michele, Schenk, Dale, St. George-Hyslop, Peter, Mandelkow, Eva M., Dobson, Christopher M., McConlogue, Lisa, Mandelkow, Eckhard, Tóth, Gergely
Natura: Artigo
Lingua:Inglês
Pubblicazione: Bentham Science Publishers 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976804/
https://ncbi.nlm.nih.gov/pubmed/26510979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/156720501209151019104951
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