Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

BACKGROUND: A certain number of mutations in the Microtubule-Associated Protein Tau (MAPT) gene have been identified in individuals with high risk to develop neurodegenerative diseases, collectively called tauopathies. The mutation A152TMAPT was recently identified in patients diagnosed with frontot...

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Bibliographic Details
Published in:Mol Neurodegener
Main Authors: Pir, Ghulam Jeelani, Choudhary, Bikash, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847334/
https://ncbi.nlm.nih.gov/pubmed/27118310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0096-1
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