Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

BACKGROUND: A certain number of mutations in the Microtubule-Associated Protein Tau (MAPT) gene have been identified in individuals with high risk to develop neurodegenerative diseases, collectively called tauopathies. The mutation A152TMAPT was recently identified in patients diagnosed with frontot...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Pir, Ghulam Jeelani, Choudhary, Bikash, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847334/
https://ncbi.nlm.nih.gov/pubmed/27118310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0096-1
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