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Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

BACKGROUND: A certain number of mutations in the Microtubule-Associated Protein Tau (MAPT) gene have been identified in individuals with high risk to develop neurodegenerative diseases, collectively called tauopathies. The mutation A152TMAPT was recently identified in patients diagnosed with frontot...

詳細記述

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書誌詳細
出版年:Mol Neurodegener
主要な著者: Pir, Ghulam Jeelani, Choudhary, Bikash, Mandelkow, Eckhard, Mandelkow, Eva-Maria
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847334/
https://ncbi.nlm.nih.gov/pubmed/27118310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0096-1
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