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The Tau/A152T mutation, a risk factor for frontotemporal‐spectrum disorders, leads to NR2B receptor‐mediated excitotoxicity
We report on a novel transgenic mouse model expressing human full‐length Tau with the Tau mutation A152T (hTau(AT)), a risk factor for FTD‐spectrum disorders including PSP and CBD. Brain neurons reveal pathological Tau conformation, hyperphosphorylation, mis‐sorting, aggregation, neuronal degenerati...
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| Publicado no: | EMBO Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4818782/ https://ncbi.nlm.nih.gov/pubmed/26931569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541439 |
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