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Adenosine A(1) receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280
Accumulation of Tau is a characteristic hallmark of several neurodegenerative diseases but the mode of toxic action of Tau is poorly understood. Here, we show that the Tau protein is toxic due to its aggregation propensity, whereas phosphorylation and/or missorting is not sufficient to cause neurona...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5068267/ https://ncbi.nlm.nih.gov/pubmed/27671637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603119113 |
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