Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues

Mutations create genetic variation for other evolutionary forces to operate on and cause numerous genetic diseases. Nevertheless, how de novo mutations arise remains poorly understood. Progress in the area is hindered by the fact that error rates of conventional sequencing technologies (1 in 100 or...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Arbeithuber, Barbara, Hester, James, Cremona, Marzia A., Stoler, Nicholas, Zaidi, Arslan, Higgins, Bonnie, Anthony, Kate, Chiaromonte, Francesca, Diaz, Francisco J., Makova, Kateryna D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363077/
https://ncbi.nlm.nih.gov/pubmed/32667908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000745
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