Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues

Mutations create genetic variation for other evolutionary forces to operate on and cause numerous genetic diseases. Nevertheless, how de novo mutations arise remains poorly understood. Progress in the area is hindered by the fact that error rates of conventional sequencing technologies (1 in 100 or...

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Detaylı Bibliyografya
Yayımlandı:PLoS Biol
Asıl Yazarlar: Arbeithuber, Barbara, Hester, James, Cremona, Marzia A., Stoler, Nicholas, Zaidi, Arslan, Higgins, Bonnie, Anthony, Kate, Chiaromonte, Francesca, Diaz, Francisco J., Makova, Kateryna D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363077/
https://ncbi.nlm.nih.gov/pubmed/32667908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000745
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