Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues

Mutations create genetic variation for other evolutionary forces to operate on and cause numerous genetic diseases. Nevertheless, how de novo mutations arise remains poorly understood. Progress in the area is hindered by the fact that error rates of conventional sequencing technologies (1 in 100 or...

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Dettagli Bibliografici
Pubblicato in:PLoS Biol
Autori principali: Arbeithuber, Barbara, Hester, James, Cremona, Marzia A., Stoler, Nicholas, Zaidi, Arslan, Higgins, Bonnie, Anthony, Kate, Chiaromonte, Francesca, Diaz, Francisco J., Makova, Kateryna D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363077/
https://ncbi.nlm.nih.gov/pubmed/32667908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000745
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