TRIGGERING ANAPHASE CATASTROPHE TO COMBAT ANEUPLOID CANCERS

Cancer cells are genetically unstable and often have supernumerary centrosomes. When supernumerary centrosome clustering is inhibited at mitosis, multipolar cell division is forced, triggering apoptosis in daughter cells. This proapoptotic pathway is called anaphase catastrophe. Cyclin-dependent kin...

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Published in:Trans Am Clin Climatol Assoc
Main Authors: DMITROVSKY, ETHAN, KAWAKAMI, MASANORI, LIU, XI, FREEMANTLE, SARAH J., KURIE, JONATHAN M.
Format: Artigo
Language:Inglês
Published: American Clinical and Climatological Association 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7358487/
https://ncbi.nlm.nih.gov/pubmed/32675848
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