Fragment-based Differential Targeting of PPI Stabilizer Interfaces

[Image: see text] Stabilization of protein–protein interactions (PPIs) holds great potential for therapeutic agents, as illustrated by the successful drugs rapamycin and lenalidomide. However, how such interface-binding molecules can be created in a rational, bottom-up manner is a largely unanswered...

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Opis bibliograficzny
Wydane w:J Med Chem
Główni autorzy: Guillory, Xavier, Wolter, Madita, Leysen, Seppe, Neves, João Filipe, Kuusk, Ave, Genet, Sylvia, Somsen, Bente, Morrow, John Kenneth, Rivers, Emma, van Beek, Lotte, Patel, Joe, Goodnow, Robert, Schoenherr, Heike, Fuller, Nathan, Cao, Qing, Doveston, Richard G., Brunsveld, Luc, Arkin, Michelle R., Castaldi, Paola, Boyd, Helen, Landrieu, Isabelle, Chen, Hongming, Ottmann, Christian
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2020
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7356319/
https://ncbi.nlm.nih.gov/pubmed/32501690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01942
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