Fragment-based Differential Targeting of PPI Stabilizer Interfaces

[Image: see text] Stabilization of protein–protein interactions (PPIs) holds great potential for therapeutic agents, as illustrated by the successful drugs rapamycin and lenalidomide. However, how such interface-binding molecules can be created in a rational, bottom-up manner is a largely unanswered...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Guillory, Xavier, Wolter, Madita, Leysen, Seppe, Neves, João Filipe, Kuusk, Ave, Genet, Sylvia, Somsen, Bente, Morrow, John Kenneth, Rivers, Emma, van Beek, Lotte, Patel, Joe, Goodnow, Robert, Schoenherr, Heike, Fuller, Nathan, Cao, Qing, Doveston, Richard G., Brunsveld, Luc, Arkin, Michelle R., Castaldi, Paola, Boyd, Helen, Landrieu, Isabelle, Chen, Hongming, Ottmann, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7356319/
https://ncbi.nlm.nih.gov/pubmed/32501690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01942
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