Increased chemotherapy-induced ovarian reserve loss in women with germline BRCA mutations due to oocyte deoxyribonucleic acid double strand break repair deficiency

OBJECTIVE: To assess whether woman who have BRCA mutations (WBM) experience more declines in ovarian reserve after chemotherapy treatment, as it induces oocyte death by deoxyribonucleic acid (DNA) damage, and BRCA mutations result in DNA damage repair deficiency. DESIGN: Longitudinal cohort study. S...

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Published in:Fertil Steril
Main Authors: Oktay, Kutluk H., Bedoschi, Giuliano, Goldfarb, Shari B., Taylan, Enes, Titus, Shiny, Palomaki, Glenn E., Cigler, Tessa, Robson, Mark, Dickler, Maura N.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7339936/
https://ncbi.nlm.nih.gov/pubmed/32331767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fertnstert.2020.01.033
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